Faculty Directory
Madhav Mani

Assistant Professor of Engineering Sciences and Applied Mathematics


2145 Sheridan Road
Evanston, IL 60208-3109

Email Madhav Mani


Madhav Mani Research


Engineering Sciences and Applied Mathematics


PhD Program in Interdisciplinary Biological Sciences

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Ph.D Applied Mathematics, Harvard University, Cambridge, MA

S.M. Engineering Sciences, Harvard University, Cambridge, MA

Masters of Advanced Studies in Mathematics and Theoretical Physics, Cambridge University, England

M.A. in Mathematics and Theoretical Physics, Trinity Hall, Cambridge University, England

B.A. in Mathematics and Theoretical Physics, Trinity Hall, Cambridge University, England

Research Interests

This is an exciting time to be studying organismal development. In spite of the progress in molecular biology built up over the last 3 decades, we are still searching for the mechanisms that couple the chemical and physical forms of organism. A misshaped hand, even with the right proportions of different cell types, wouldn't be of much use in gripping a cup of coffee. What are the collective cellular and tissue level mechanisms that generate the complex multicellular patterns of cellular differentiation and morphology in organisms? Recent advance in live fluorescent imaging provide us with a dynamic and spatially resolved view of organismal development, and what is needed now is the development of mathematical tools and models that can help ushering in a new, and physical, understanding of organismal biology.

In close collaboration with experimental labs around the world, my group develops quantitative image-analysis tools and mathematical models that guide the construction of inverse modeling schemes to make new and better measurements of live imaging data. When required, forward mathematical models are constructed to make sense of emergent phenomena, and more importantly, to generate predictions and hypotheses that guide future experimentation.

Significant Recognition

  • Simons Postdoctoral Fellowship, 2010 - 2013
  • Derek Bok Undergraduate Teaching Award, Harvard University, 2009
  • Robert L. Wallace Prize Fellowship, Harvard University, 2007 - 2008

Selected Publications

    Collective Polarization and gradient sensing in the Fat pathway: M. Mani, S. Goyal, K. Irvine, B.I. Shraiman (Proceedings of the National Academy of Sciences 110.51 - 2013)

    Principles of E-cadherin supramolecular organization in vivo: B.A.T. Quang, M. Mani, O. Markova, T. Lecuit, P-F. Lenne (Current Biology 23.22 - 2013)

    Propagation of Dachsous-Fat Planar Cell Polarity, A. A. Ambegaonkar, G. Pan, M. Mani, Y. Feng, K. D. Irvine (Current Biology, Volume 22 June 2012)

    Physical ageing of the contact line on colloidal particles at liquid interfaces David M. Kaz, Ryan McGorty, M. Mani, Michael P. Brenner, and Vinothan N. Manoharan (Nature Materials, 11, 138-142 - 2012)

    How Things Get Stuck: Kinetics, Elastohydrodynamics, and Soft Adhesion M. Mani, Arvind Gopinath, and L. Mahadevan (Phys. Rev. Lett. 108, 226104 - 2012)

    Self assembly of magnetically interacting cubes by a turbulent fluid flow: Filip Ilievski, M. Mani, G. Whitesides, M.P. Brenner (Phys. Rev. E, 83, 017301 - 2011)

    Events before droplet splashing on a solid surface: M. Mani, S. Mandre, M. Brenner (J. Fluid Mech., 647, 163 - 2010)

    Precursors to splashing of liquid droplets on a solid surface: S. Mandre, M. Mani, M. Brenner (Phys. Rev. Lett. 102, 134502, 2009)

    Botanical ratchets: I. Kulic, M. Mani, H. Mohrbach, R. Thaokar, L. Mahadevan (Proceedings of the Royal Society of London (B), Biological Sciences, 276, 2243-47, 2009)